Coronary interventions

In vitro effect of intravascular lithotripsy on the polymer of a drug-eluting stent

EuroIntervention 2022;18:e333-e334. DOI: 10.4244/EIJ-D-22-00300

Alexandru Achim
Alexandru Achim1, MD; Carola Alampi2, MD; Lian Krivoshei1, MD; Gregor Leibundgut1, MD
1. Klinik für Kardiologie, Medizinische Universitätsklinik, Kantonsspital Baselland, Liestal, Switzerland; 2. BioEM Lab, Biozentrum, University of Basel, Basel, Switzerland


Figure 1. Comparison of the effect of lithotripsy and a resistant calcified lesion on the fluoropolymer of an everolimus-eluting stent. DES: drug-eluting stent; IVL: intravascular lithotripsy

Intravascular lithotripsy (IVL) delivers localised pulsatile sonic pressure waves to circumferentially disrupt vascular calcium with promising results1. Although initially introduced for lesion preparation and plaque modification, it has recently been used for the treatment of underexpanded drug-eluting stents (DES)23. However, no clear evidence exists as to whether the sonic pressure waves affect the polymer and, subsequently, the antiproliferative drug of a freshly implanted DES. This may result in downstream effects, such as distal ...

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