Functional assessment of coronary stenosis with angiography-based Quantitative Flow Ratio compared with Fractional Flow Reserve in patients with severe aortic stenosis.
Main Authors: Hernan Mejia-Renteria1; Luis Nombela-Franco1; Jean-Michel Paradis2; Mattia Lunardi3; Joo Myung Lee4; Ignacio J. Amat-Santos5; Gabriela Veiga6; Ankur Kalra7; Eric J Bansal8; Jose Maria de la Torre Hernandez6; Josep Rodes-Cabau2; Flavio Ribichini3; Javier Escaned9;
Collaborators: Gabriele Venturi10; Alfredo Nunes Ferreira-Neto2; Catherine Liontou1; Rafael Vera1; Francesco Maria Lauri1; Fernando Macaya1; Sonoka Goto1; Angela McInerney1; Jihoon Kim11; Ki-Hong Choi11; Carlos Cortes5; Gabriela Tirado-Conte1; German Armijo1; Pilar Jiménez-Quevedo1; Nieves Gonzalo1; Ivan J. Nuñez-Gil1; Pablo Salinas1; Antonio Fernandez-Ortiz1; Carlos Macaya1;
1. Hospital Clínico San Carlos, IDISSC and Universidad Complutense de Madrid, Madrid; Spain. 2. Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada 3. Cardiovascular Division, Department of Medicine, University of Verona, Italy. 4. Department of Internal Medicine and Cardiovascular Centre, Heart Vascular Stroke Institute, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. 5. CIBERCV, Cardiology Department, ICICORELAB, Hospital Clínico Universitario, Valladolid, Spain. 6. Department of Cardiology, Hospital Universitario Marques de Valdecilla, Santander, Spain. 7. Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA. 8. Division of Cardiovascular Medicine, Harrington Heart & Vascular Institute, University Hospitals Cleveland Medical Centre, Cleveland, Ohio, USA. 9. Hospital Clinics San Carlos, IDISSC and Universidad Complutense de Madrid, Madrid; Spain, Spain 10. Cardiovascular Division, Department of Medicine, University of Verona, Italy 11. Department of Internal Medicine and Cardiovascular Centre, Heart Vascular Stroke Institute, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
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Aims: To investigate the diagnostic performance of quantitative flow ratio (QFR) in assessing the physiological relevance of coronary lesions in the presence of severe aortic valve stenosis (SAS).
Methods and Results: 115 SAS patients (138 coronary arteries) were included. Functional assessment of coronary stenoses was performed with fractional flow reserve (FFR) before transcatheter aortic-valve implantation (TAVI). Subsequently, QFR was calculated at a central core laboratory, blinded to FFR results. The diagnostic yield of QFR was assessed using FFR as reference. Coronary stenoses were intermediate (diameter stenosis 48±10%, FFR 0.84 [0.77-0.89], QFR 0.82 [0.73-0.89]). Per-vessel sensitivity, specificity, area under the ROC curve and accuracy of QFR were 84% (95% CI 71-92%), 80% (95% CI 69-88%), 0.88 (95% CI 0.82-0.93) and 81%, respectively. Diagnostic accuracy of QFR significantly decreased in patients with aortic valve area (AVA) <0.60 cm2. Diagnostic performance of QFR was superior to angiography in assessing the FFR-based functional significance (AUC 0.88 [95% CI 0.82-0.93] vs. 0.74 [95% CI 0.66-0.81], respectively; p = 0.0002). Conclusions: Compared with FFR, QFR has a good diagnostic yield and is superior to angiography in assessing the functional relevance of coronary lesions in SAS patients awaiting TAVI, particularly when AVA is ≥0.6 cm2.