Coronary Interventions - Mini Focus on Stent Restenosis

Quantitative flow ratio for functional evaluation of in-stent restenosis

EuroIntervention 2021;17:396-398. DOI: 10.4244/EIJ-D-18-00955

Catherine Liontou
Catherine Liontou1, MD, PhD; Hernán Mejía-Rentería1, MD; Francesco Maria Lauri1, MD; Sonoka Goto1,2, MD; Hyun-Jong Lee3, MD, PhD; Masafumi Nakayama2,4, MD, PhD; Alicia Quirós5, PhD; Fernando Macaya1, MD; Nieves Gonzalo1, MD, PhD; Iván J. Núñez-Gil1, MD, PhD; Pablo Salinas1, MD, PhD; Maria Del Trigo1, MD, PhD; Javier Escaned1, MD, PhD
1. Hospital Clínico San Carlos IDISSC and Universidad Complutense de Madrid, Madrid, Spain; 2. Cardiovascular Center, Toda Chuo General Hospital, Toda, Japan; 3. Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea; 4. Joint Graduate School of Tokyo Women’s Medical University and Waseda University, Tokyo, Japan; 5. Department of Mathematics, Universidad de León, León, Spain

Coronary angiography is the most common diagnostic tool to assess in-stent restenosis (ISR) severity, both in clinical practice and in trials1. However, given its poor ability to depict the relevance of functional stenosis, fractional flow reserve (FFR) has been proposed as the reference standard to ascertain functional ISR severity2. More recently, quantitative flow ratio (QFR) has been validated in de novo lesions as an angiography-based approach to functional stenosis characterisation that does not require intracoronary instrumentation3. We investigated the diagnostic performance of QFR in ISR lesions, using FFR as the reference standard.


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Coronary interventionsInterventions for valvular diseaseInterventions for heart failurePeripheral interventionsInterventions for hypertensionInterventions for strokeSTEMINSTEMIStable CADStents and scaffoldsLeft main and multivessel diseaseCTOOther coronary interventionsTAVIMitral valve replacement and repairTricuspid / Pulmonary valveOther valvular and structural interventionsAcute heart failureChronic heart failureAAARenal denervationLAA closure
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