Exercise-induced myocardial ischaemia is a major prognostic indicator, and reliable assessment is a daily challenge1,2. Simple angiography sheds no light on ischaemia risk in coronary stenosis3, as accuracy is only 65%, compared to 95% with adenosine-derived fractional flow reserve (FFR)4. Moreover, coronarography is usually performed without a preliminary non-invasive test or with ambiguous results, especially in multivessel disease5.
An exemplary, rigorous step-by-step methodology by Nico H.J. Pijls and Bernard De Bruyne has been implemented for 20 years now, covering all pathophysiological stages of functional assessment of atherosclerotic epicardial coronary stenosis.
Clinical studies of FFR have explored the various clinical ...
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