The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)


Reply to the letter to the editor by Yaeger regarding the article “In vivo validation of mathematically derived fractional flow reserve for assessing haemodynamics of coronary tandem lesions”

EuroIntervention 2018;13:2080-2082. DOI: 10.4244/EIJV13I17A341

We appreciate the interest in our article1. The author raised the issues of the driving force for myocardial flow, the flow ratio estimation, and the procedural order. Also, the author suggested that the application of the prediction model in Yaeger2 would improve the outcomes of FFR prediction.

Spaan et al3 showed that, even without collateral flows, (Pd–Pv)/(Pa–Pv) overestimates the coronary flow ratio (QS/QN) and the microvascular resistance (Rmin) increases as the distal pressure (Pd) falls. To build an equation to describe the P–Q relationship better, we introduced “R” corresponding to the inverse of ...

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