The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)

LETTER TO THE EDITOR

Reply to the letter to the editor by Saito regarding the article “In vivo validation of mathematically derived fractional flow reserve for assessing haemodynamics of coronary tandem lesions”

EuroIntervention 2018;13:2078. DOI: 10.4244/EIJV13I17A339

Department of Cardiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea


We appreciate the interest in our article1. The author (N. Saito) raised the issue of fundamental errors in the primary assumption for the mathematical model of FFR post-stenting and suggested that the application of the prediction model in Yamamoto et al2 would improve the outcomes of FFR prediction.

The flow rate (Q) in our derivation is defined as the coronary flow (not as the perfusion flow), which determines the translesional pressure gradient3. It is well established that the coronary flow is proportional to the difference between the distal pressure and the wedge pressure4. This is also the first ...

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