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Diagnosing prediabetes for assessing its effect on prognosis after coronary intervention – are fasting glucose and glycosylated haemoglobin enough?

EuroIntervention 2019;14:e1619-e1620 published online e-edition February 2019. DOI: 10.4244/EIJ-D-18-00235L

1. Department of Cardiology, Milton Keynes University Hospital, Milton Keynes, United Kingdom; 2. Department of Cardiology, Castle Hill Hospital, Kingston upon Hull, United Kingdom

We read with interest the paper by Kok et al1. It concludes that prediabetes mellitus (pDM) imposes a higher risk of major adverse cardiovascular events (MACE) than normoglycaemia (NG) in patients, two thirds with acute coronary syndrome (ACS), undergoing coronary stenting.

pDM was defined on the basis of HbA1c and fasting plasma glucose (FPG). In the absence of two-hour post-load glucose (2 hr-PG), it is unclear as to how many of the pDM patients had impaired glucose tolerance (IGT) or DM. It is widely accepted that FPG and HbA1c underdiagnose DM and do not diagnose IGT2,3. The ...

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Reply to the letter to the editor regarding the article “Prediabetes and its impact on clinical outcome after coronary intervention in a broad patient population”