The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)


Continuous development of neoatherosclerosis beyond a decade after drug-eluting stent implantation

EuroIntervention 2018;14:e1255-e1257. DOI: 10.4244/EIJV14I12A226

Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan

Coronary stents are widely used for the treatment of patients with coronary artery disease. Drug-eluting stents (DES) have reduced the rate of late restenosis compared with bare metal stents (BMS). However, late and very late stent thrombosis have become a major concern in DES. Pathological findings from patients who died of very late DES thrombosis have demonstrated that incomplete re-endothelialisation, late acquired stent malapposition, and atherosclerosis within neointima (known as neoatherosclerosis) are important underlying substrates of very late DES thrombosis1. Rupture of neoatherosclerosis is the most common mechanism of very late DES thrombosis. Neoatherosclerosis in DES occurs earlier compared ...

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