Combined functional and anatomical assessment of coronary stenosis by coronary CT angiography

During the last decade, extensive literature has confirmed the high diagnostic accuracy of coronary computed tomography angiography (CCTA) for the detection of coronary stenosis using invasive coronary angiography (ICA) as gold standard1. Based on these data and the findings of large prospective trials, such as PROMISE and SCOT-HEART, CCTA has been definitively integrated into the routine clinical management of patients with suspected coronary artery disease (CAD) as the first-line diagnostic and prognostic method2,3. The ESC Guidelines on the management of stable CAD recommend CCTA with a Class I level of evidence4. However, relying only on anatomical information with CCTA has ...