2. Department of Cardiothoracic Surgery and Interventional Cardiology, Houston-Methodist-Debakey Heart and Vascular Center, Houston, TX
3. Department of Cardiology, Riverside Methodist – Ohio Health, Columbus, OH
4. Departments of Cardiothoracic Surgery and Interventional Cardiology, Spectrum Health Hospitals, Grand Rapids, Michigan
5. Department of Interventional Cardiology, University Hospital Bern, Bern, Switzerland
6. Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA
7. Cardiac Surgery, Cedars-Sinai Medical Center, Los Angeles, CA
8. Interventional Cardiology, Saint Thomas Heart, Ascension Medical Group, Nashville, TN
9. Interventional Cardiology, Cardiovascular Institute of the South, Houma, LA
10. Interventional Cardiology, Baylor Scott & White Heart and Vascular Hospital, Dallas, TX
11. Cardiothoracic Surgery, Baylor Scott & White Heart and Vascular Hospital, Dallas, TX
12. International Centre for Circulatory Health, NHLI, Imperial College London, London, United Kingdom
13. Department of Interventional Cardiology, Beth Israel Deaconess Medical Center, Boston, MA
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(TAVI) or surgical aortic valve replacement (SAVR), sex-specific differences in complication rates are unclear in intermediate-risk patients. METHODS AND RESULTS: 1,660 intermediate-risk patients underwent TAVI with a supra-annular, self-expanding bioprosthesis or SAVR. The population was stratified by sex and treatment modality (female TAVI=366, male TAVI=498, female SAVR=358, male SAVR=438). The primary endpoint was a composite of all-cause mortality or disabling stroke at two years. Compared to males, females had a smaller body surface area, a higher Society of Thoracic Surgeons score (4.7±1.6% vs. 4.3±1.6%, p<0.01) and more frailty. Men required more concomitant revascularization (23% vs. 16%). All-cause mortality or disabling stroke at two years was similar between TAVI and SAVR for females (10.2% vs. 10.5%, p=0.90) and males
(14.5% vs. 14.4%, p=0.99); the difference between females and males was 10.2% vs. 14.5%, for TAVI (p=0.08) and 10.5% vs. 14.4%, SAVR (p=0.13). Functional status improvement was more pronounced after TAVI for females than males. CONCLUSIONS: Aortic valve replacement, either by surgical or transcatheter approach, appears similarly effective and safe for males and females at intermediate surgical risk. Functional status appears to improve most in females after TAVI.
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