The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)

Interventions for valvular disease and heart failure

Active tracked intramyocardial catheter injections for regenerative therapy with real-time MR guidance: feasibility in the porcine heart

EuroIntervention 2019;15:e336-e339. DOI: 10.4244/EIJ-D-17-01081

1. Division of Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands; 2. Netherlands Heart Institute (NHI), Utrecht, the Netherlands; 3. Institute for Complex Molecular Systems, Department of Biomedical Engineering, Laboratory of Chemical Biology, Eindhoven University of Technology, Eindhoven, the Netherlands; 4. Image Sciences Institute, University Medical Center Utrecht, Utrecht, the Netherlands; 5. Philips Research Laboratories, Best, The Netherlands; 6. Imricor Medical Systems, Burnsville, MN, USA; 7. CART-Tech B.V., Utrecht, the Netherlands


Introduction

The use of magnetic resonance imaging (MRI) for guidance of interventional procedures (iMRI) has distinct advantages over fluoroscopy. MRI lacks ionising radiation, has superb soft tissue contrast and provides functional data. Although iMRI is not suitable for all patient categories (e.g., cardiac devices), its potential has already been demonstrated for various interventions1,2.

Within the field of cardiac regenerative therapy there is a need for improved delivery of therapies3. Currently, regenerative therapy is applied via coronary infusion or electro-anatomical mapping-guided injections. Because late gadolinium (LG)-MRI is the gold standard for infarct assessment and allows real-time ...

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