1. Hôpital de la Tour, Geneva, Switzerland; 2. Ramsay Générale de Santé, Institut Cardiovasculaire Paris Sud, Massy, France
Thirteen years ago, the ELUTES trial first suggested that paclitaxel-coated stents might reduce restenosis without requiring a polymer1. However, further evaluation of similar devices was disappointing, so that the first permanent polymer-coated drug-eluting stents (DES) became the early accepted standard2-4. Over time, however, late thrombotic complications became apparent and were largely attributed to the polymer coatings5. Prolonged or indefinite dual antiplatelet therapy (DAPT) was then considered necessary by many until improved permanent and biodegradable polymers were shown to be safer, allowing the pendulum to begin slowly to swing towards less aggressive antithrombotic regimens6. More recently, thanks to better ...
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