Clinical research

DOI: 10.4244/EIJ-D-22-01110

Percutaneous paravalvular leak closure after transcatheter aortic valve implantation: the international PLUGinTAVI Registry

Eduardo Flores-Umanzor1, MD; Jason Nogic2, MD; Pedro Cepas-Guillén3, MD; Sebastien Hascoet4, MD; Piotr Pysz5, MD; Jose Antonio Baz6, MD; Ignacio Cruz-González7, MD; Ignacio J. Amat-Santos8,9, MD; Pablo Antúnez-Muiños7, MD; Jose Carlos González8, MD; Valeriano Ruíz-Quevedo10, MD; Rodrigo Estevez-Loureiro6, MD; Benoit Gerardin4, MD; Xavier Millan11, MD; Marcel Santaló-Corcoy12, MD; Ander Regueiro3, MD; Réda Ibrahim12, MD; Dabit Arzamendi8, MD; Eustaquio Maria Onorato13, MD; Josep Rodés-Cabau14, MD; Eric Horlick1, MD; Patrick A. Calvert2, MD; Xavier Freixa3, MD

Abstract

Background: Data regarding the safety and long-term effectiveness of percutaneous closure of paravalvular leak (PVL) after transcatheter aortic valve implantation (TAVI) are scarce.

Aims: This study aims to present a large multicentre international experience of percutaneous post-TAVI PVL closure.

Methods: All patients who underwent percutaneous post-TAVI PVL closure in 14 hospitals across Europe and North America between January 2018 and October 2022 were included.

Results: Overall, 45 patients (64% male) were enrolled. The median age was 80 years (75-84). Among them, 67% and 33% had self-expanding and balloon-expandable valve implantations, respectively. Baseline post-TAVI PVL was severe in 67% of cases and moderate in the rest. The time from index TAVI to PVL closure procedure was 16.1 (8.7-34.8) months. Most patients were in NYHA Class III and IV (73%) before the procedure, and 40% had referred hospitalisations for heart failure between TAVI and the PVL closure procedure. Successful PVL closure was achieved in 94%, reducing regurgitation to ≤mild in 91% and moderate in the rest. The Amplatzer Valvular Plug III was the most frequently used device (27 cases), followed by the Amplatzer Valvular Plug 4. The incidence of severe adverse events was 11%. None of the patients died during the index hospitalisation. During long-term follow-up (21.7±16.2 months), the all-cause mortality rate was 14%, and patients presented improvement in functional status and a significant reduction in the rate of hospitalisation for heart failure (from 40% to 6%).

Conclusions: Percutaneous PVL closure is a feasible and safe option for treating post-TAVI leaks. Successful PVL reduction to mild or less could be associated with acute and long-lasting improvements in clinical outcomes.

Introduction

Transcatheter aortic valve implantation (TAVI) has emerged as a breakthrough treatment for patients with symptomatic severe aortic stenosis (AS)1. Given its minimally invasive approach, TAVI has become the first treatment option in older patients, improving their prognosis and quality of life compared to surgical aortic valve replacement23. Paravalvular leakage (PVL) is among the most common complications post-TAVI4, with a prevalence that ranges from 7% to 40%5. More than mild post-TAVI PVL negatively impacts long-term outcomes, even in asymptomatic patients6. In fact, moderate to severe post-TAVI PVLs are associated with a twofold increase in overall all-cause mortality5.

Improved transcatheter valve design has resulted in a decline in PVL after TAVI57. Nonetheless, post-TAVI PVLs still happen, which demand potential corrective measures8910. Possible causation mechanisms include valve underexpansion, valve malposition, and a high burden of annular or left ventricular outflow calcium89. Both balloon dilatation and valve-in-valve implantation reduce their occurrence but are associated with increased complications (need for a pacemaker and aortic annulus rupture) and procedural costs, respectively. Transcatheter post-TAVI PVL closure with vascular plugs may represent another valid option.

Data regarding the safety and long-term effectiveness of percutaneous post-TAVI PVL closure are scarce, limited to case reports, small case series, and a recently published registry10111213. This study aims to present a large, international, multicentre experience of percutaneous post-TAVI PVL closure, including feasibility, safety, and long-term outcomes.

Methods

Study population and clinical data

The PLUGinTAVI Working Group Registry retrospectively collected data from consecutive patients undergoing percutaneous PVL closure after TAVI at a total of 14 sites in Europe and North America between January 2018 and October 2022. The mean number of cases per centre per year was 200 (±50). Sites were contacted by the principal investigator (X. Freixa) and invited to participate in the registry. Patients were included in the registry irrespective of the type of TAVI, and the selection of any procedural features (device, access, imaging, implantation technique, etc.,) was at the operators’ discretion. Our cohort of patients only included patients with PVL; intravalvular leaks were excluded from the analysis. The final decision to perform PVL closure was made by the Heart Team of each centre. In general, the management of multiple PVLs corresponded to their severity. When ≥2 PVLs existed, the primary target of intervention was the largest and most significant leak, which the Heart Team considered responsible for the patient’s clinical symptoms. In case of persistent leaks after the first PVL closure, most operators adopted a tailored patient approach based on their severity and the potential impact on symptoms.

A dedicated database was used to collect baseline characteristics, periprocedural percutaneous PVL closure features, and clinical/echocardiographic in-hospital and follow-up outcomes. All patients gave written informed consent before the procedure, and the study was performed in accordance with the local ethics committee of each centre. The study conformed to the guiding principles of the Declaration of Helsinki.

Definitions and procedure

The patient’s functional status was evaluated before and after PVL closure and classified based on the New York Heart Association (NYHA) Functional Class. Functional Class data from successful PVL closures were obtained from medical records in routine follow-up visits, mostly at 1, 6, and 12 months after leak closure. The Society of Thoracic Surgery Predicted Risk of Mortality (STS-PROM) and the European System for Cardiac Operative Risk Evaluation (EuroSCORE II) were used to evaluate the surgical risk. A 3-class scheme (mild, moderate, severe) was used to evaluate paravalvular regurgitation before and after PVL closure following the recommendation of the American Society of Echocardiography (ASE) and European Association of Cardiovascular Imaging (EACVI) guidelines14. In the present study, PVL was primarily assessed by transthoracic echocardiogram (TTE)/transoesophageal echocardiogram (TOE) before the intervention. In a minority of cases, computed tomography angiography (CTA) was also used for localisation, defect sizing, and procedural planning purposes. Procedural success was defined as the successful closure of PVL with a reduction of at least one grade of paravalvular regurgitation1516. Procedural and major adverse events (MAEs) were reported according to Valve Academic Research Consortium 3 criteria17. Serious adverse events (SAEs) were defined as intraprocedural death, cardiac tamponade, stroke, device embolisation, major vascular complications, and major bleeding events. Major bleeding events were defined as type 3 or greater on the Bleeding Academic Research Consortium (BARC) scale18. Clinical follow-up was carried out through patient visits, medical report reviews, and phone contact. Adverse events reported at follow-up included death (cardiovascular and non-cardiovascular), heart failure (HF) hospitalisation, stroke, post-TAVI endocarditis, and aortic reintervention. A reduction in hospitalisation for HF was found after comparing the number of patients with an implanted TAVI and ≥1 hospitalisation for HF before and after successful PVL closure.

Statistical analysis

Categorical variables are presented as frequencies (percentages). Continuous variables are presented as a mean±standard deviation (SD) or median (interquartile range). The Kolmogorov-Smirnov test was applied to ensure normal distribution. Follow-up was terminated at the date of the final follow-up for each patient. Analyses were performed using STATA software, version 14.0 (StataCorp).

Results

Baseline characteristics

Data on all post-TAVI transcatheter PVL closures performed in the participating centres were collected. The study included 45 patients with a median age of 80 years (75-84), of whom 64% were men. The mean STS score and EuroSCORE II were 5.8±5.3 and 6.3±5.7, respectively. PVL closure was performed at a median of 16.1 months (8.7-34.8) after the index TAVI. Most patients (91%) presented with HF symptoms, while 2% presented with isolated haemolysis, and 7% had both HF and haemolysis. Prior to the leak closure, 73% of patients were in NYHA Class III and IV. Hospitalisations for HF between the index TAVI and PVL closure occurred in 40% of patients. Single antiplatelet therapy (SAPT) (53%) was the most common antithrombotic therapy prescribed before the procedure. A self-expanding valve was used in 67% of cases, and a balloon-expandable valve was used in the remaining 33%. Replacement valve sizes ranged from 26 to 31 mm. PVL was severe in 67% of cases and moderate in the remaining cases. Baseline clinical and echocardiographic characteristics are summarised in Table 1 and Table 2. Patients who received a balloon-expandable valve had a longer time interval between TAVI and the PVL closure than those who received a self-expanding valve (p=0.02). No other significant differences were observed between the two groups. Supplementary Table 1 presents detailed information on clinical and echocardiography outcomes at maximum follow-up, based on valve type.

Table 1. Baseline demographic characteristics.

Total (n=45)
Age, years 80 (75-84)
Male gender 29 (64)
Body mass index, kg/m2 26.40±4.87
Diabetes 15 (33)
Hypertension 29 (64)
Atrial fibrillation 17 (38)
Previous CAD 22 (49)
Previous ischaemic stroke 8 (18)
Previous peripheral artery disease 9 (20)
Chronic kidney disease 18 (40)
Liver disease 0
Creatinine, mmol/L 82.5 (67.5-97.0)
Haemoglobin, mg/dL 11.70±1.97
Platelets, 10^9/L 193.7±60.6
Previous AT treatment None 0
SAPT 24 (53)
DAPT 7 (16)
Warfarin 6 (13)
DOAC 8 (18)
Values are expressed as n (%), mean±SD, or median (IQR). AF: atrial fibrillation; AT: antithrombotic treatment; CAD: coronary artery disease; DAPT: dual antiplatelet therapy; DOAC: direct oral anticoagulation; IQR: interquartile range; SAPT: single antiplatelet therapy; SD: standard deviation; TAVI: transcatheter aortic valve implantation


Table 2.
Baseline clinical and echocardiography characteristics.

Total (n=45)
Time from TAVI procedure, months 16.1 (8.7-34.8)
Type of TAVI Balloon-expandable 15 (33)
Self-expanding 30 (67)
Type of balloon-expandable TAVI SAPIEN XT/3 13 (86)
Myval 2 (14)
Type of self-expanding TAVI Evolut R/Pro 26 (86)
ACURATE neo 3 (10)
Portico 1 (4)
Size of TAVI, mm 26 (26-31)
Main symptoms Heart failure 41 (91)
Haemolysis 1 (2)
Both 3 (7)
New York Heart Association (NYHA) I 0
II 12 (27)
III 27 (60)
IV 6 (13)
HFH between TAVI and leak procedure 18 (40)
EuroSCORE II 6.3±5.7
STS score 5.8±5.3
Left ventricular ejection fraction 52.0±10.7
Paravalvular aortic regurgitation Mild 0
Moderate 15 (33)
Severe 30 (67)
Aortic gradient, mmHg 7.0 (3.5-11.6)
Mitral regurgitation No 9 (20)
Mild 21 (46)
Moderate 12 (27)
Severe 3 (7)
Tricuspid regurgitation No 8 (18)
Mild 26 (58)
Moderate 7 (16)
Severe 4 (8)
Massive 0
Torrential 0
Systolic pulmonary artery pressure, mmHg (n=26) 41.5 (30.0-57.5)
Values are expressed as n (%), mean±SD, or median (IQR). EuroSCORE: European System for Cardiac Operative Risk Evaluation; IQR: interquartile range; HFH: heart failure hospitalisation; SD: standard deviation; STS: Society of Thoracic Surgeons; TAVI: transcatheter aortic valve implantation

Procedural characteristics

Successful PVL closure was achieved in most patients (94%), reducing regurgitation to ≤mild in 91% of cases, while moderate regurgitation persisted in the remaining cases. The reasons for PVL closure failure are listed in Supplementary Table 2. The majority of patients (61%) presented with a single PVL, while 35% exhibited two leaks, and only a small proportion (4%) had three. Most PVLs were found to be located at the left (49%) or non-coronary cusps (31%) and more than one leak was treated in 13% of cases.

The procedure was performed under local anaesthesia in 58% of cases and general anaesthesia in 42%, with guidance mainly by TOE (42%), followed by angiography+transthoracic echocardiography (36%) and intracardiac echocardiography (22%). A retrograde approach from the aorta was used in all patients, with femoral artery access in 78% and a radial approach in 22%. Secondary access was obtained via arterial or venous routes in 33% and 11%, respectively, and an arterio-arterial loop was utilised in 23% of cases. The use of an arteriovenous loop was infrequent (2%).

Guiding catheters were utilised in 47% of cases and diagnostic catheters in 18%, with a mother-and-child technique used in one-quarter of cases. Delivery of devices was achieved through the use of Flexor Shuttle (Cook Medical) or Destination (Terumo) guiding sheaths in 35% of cases. The most frequently used device was the Amplatzer Vascular Plug III (AVP-3; Abbott), in different sizes (27 cases), the Amplatzer Vascular Plug 4 (AVP-4; Abbott) in 15 cases and Occlutech PLD devices (Occlutech) were used in the remaining case. A summary of the procedural characteristics is presented in Table 3.

Table 3. Procedural characteristics and in-hospital outcomes.

Total (n=45)
General anaesthesia 19 (42)
Procedural imaging Angiography+TTE 16 (36)
Standard TOE 19 (42)
Others 10 (22)
Primary access Femoral artery 35 (78)
Radial artery 10 (22)
Secondary access No 25 (55)
Arterial 15 (33)
Venous 5 (11)
Loop No 33 (75)
Arterio-arterial 11 (25)
Arteriovenous 1 (2)
Leak location Non-coronary sinus 14 (31)
Left coronary 22 (49)
Right coronary 9 (20)
Number of paravalvular leaks 1 26 (61)
2 15 (33)
3 2 (4)
Catheter used during the procedure Delivery (Destination, Flexor Shuttle) 16 (35)
Guiding 21 (47)
Diagnostic 8 (18)
Mother-and-child technique 12 (27)
More than one leak treated 6 (13)
Closure device
Amplatzer Vascular Plug 0
Amplatzer Vascular Plug II 0
Amplatzer Vascular Plug III 6/3 mm 4 (9)
10/5 mm 13 (30)
12/5 mm 2 (5)
14/5 mm 8 (19)
Amplatzer Vascular Plug 4 15 (33)
Others 1 (3)
Procedural success 42 (94)
Residual shunt No 25 (60)
Intradevice 5 (12)
Peridevice 11 (28)
Residual aortic regurgitation No 12 (29)
Mild 26 (62)
Moderate 4 (9)
Severe 0
Mean aortic gradient post-procedure, mmHg 6.5 (4.0-10.2)
Patients with procedure- or device-related SAEs ≤7 days* 5 (11)
Intraprocedural death 0
Cardiac tamponade 1 (3)
Stroke 1 (3)
Device embolisation 1 (3)
Major vascular complications 2 (5)
Major bleeding 0
Days until discharge after procedure 2 (1-6)
AT treatment at discharge None 1 (2)
SAPT 14 (33)
DAPT 12 (29)
Warfarin 6 (14)
DOAC 9 (22)
Values are expressed as n (%) or median (IQR). *Subjects may have had more than one type of major SAE event. AT: antithrombotic treatment; DAPT: dual antiplatelet therapy; DOAC: direct oral anticoagulation; IQR: interquartile range; SAE: serious adverse event; SAPT: single antiplatelet therapy; SD: standard deviation; TOE: transoesophageal echocardiography; TTE: transthoracic echocardiography

In-hospital and long-term outcomes

The rate of SAE was 11%. Nonetheless, there were no reported deaths during the index hospitalisation. One patient experienced cardiac tamponade, which was effectively treated through percutaneous drainage. Another patient experienced device embolisation, which was also managed percutaneously. In addition, there was one case of minor stroke and two major vascular complications. Following PVL closure, the median hospital stay was 2 days123456. In-hospital outcomes are presented in Table 3.

At the final follow-up (21.7±16.2 months), five patients (14%) had died. Among these deaths, two were attributed to cardiovascular causes. Table 4 presents the clinical and echocardiographic outcomes at maximum follow-up. Of the 42 patients who had successful PVL closure, long-term follow-up was available for 34 patients. During the extended follow-up, it was observed that most of the patients with previous functional impairment presented significant and sustained improvement in their functional status (NYHA I or II in 95%) following PVL closure (p<0.001) (Central illustration). The aortic regurgitation (AR) grade changed from severe (in 72%) to ≤mild (in 76%) between baseline and discharge echocardiography (p<0.001). Supplementary Figure 1 shows a maintained improvement in AR at 3-6 months and during extended follow-up. Supplementary Figure 2 illustrates that the persistent improvement in successful PVL cases, independent of the number of treated leaks, remained unchanged at 3-6 months and long-term follow-up. Figure 1 and Figure 2 illustrate the NYHA Functional Class and AR changes between baseline and maximum follow-up. Furthermore, during the follow-up period, there was a significant decrease in the rate of HF hospitalisation from 40% before PVL closure to 6% after the procedure. Only one case of infective endocarditis was noted during the follow-up period.

Table 4. Clinical and echocardiography outcomes at maximum follow-up.

Total (n=34)
Clinical outcomes
Median final follow-up, months 21.7±16.2
All-cause death 5 (14)
Cardiovascular death 2 (5)
New York Heart Association I 18 (53)
II 14 (42)
III 2 (5)
IV 0
Heart failure hospitalisation 2 (5)
Stroke 1 (3)
Endocarditis 1 (3)
Reintervention 0
Echocardiography outcomes
Residual paravalvular aortic regurgitation No 10 (30)
Mild 15 (46)
Moderate 5 (15)
Severe 3 (9)
Device embolisation 1 (3)
Device thrombosis 0
Values are expressed as n (%) or mean±SD. SD: standard deviation

Central illustration. Significant and sustained improvement in functional status following successful PVL closure comp: complications; hosp: hospitalision; NYHA: New York Heart Association; PVL: paravalvular leakage; SAE: serious adverse event; TAVI: transcatheter aortic valve implantation

Figure 1. Improvement in functional status during follow-up after successful percutaneous post-TAVI PVL closure. NYHA: New York Heart Association; PVL: paravalvular leakage; TAVI: transcatheter aortic valve implantation

Figure 2. Baseline, discharge, and follow-up grades of post-TAVI PVLs in patients who underwent successful percutaneous post-TAVI PVL closure. PVL: paravalvular leakage; TAVI: transcatheter aortic valve implantation

Discussion

The key findings of the present study, representing one of the largest multicentre international experiences of percutaneous post-TAVI PVL closure, were the following: 1) percutaneous PVL closure after self-expanding or balloon-expandable TAVI was a technically feasible procedure with a high success rate; 2) the rate of significant adverse periprocedural events in the post-TAVI PVL closure population was low; 3) a maintained reduction in AR post-TAVI PVL closure was observed in the present cohort, resulting in a sustained improvement in NYHA Functional Class; 4) a high survival rate was observed during long-term follow-up post-TAVI PVL closure.

Percutaneous post-TAVI PVL closure has already been explored, but the evidence is scarce1011121319. Percutaneous post-TAVI PVL closure is more demanding than the treatment of leaks in postsurgical conventional valves8. Native cusps are not resected during TAVI, and a high calcium volume may persist in the TAVI device landing zone, limiting accessibility and navigation of equipment between the prosthesis frame and native tissue919. Additionally, catheter progression through the valve struts may be required, and identifying the correct path to cross the defect can be extremely challenging. Furthermore, percutaneous post-TAVI PVL closure in a self-expanding valve can be more demanding than in a balloon-expandable valve, as strut avoidance is more complicated89.

Preprocedural planning is an essential aspect of percutaneous post-TAVI PVL closure. In our series, most cases were assessed by TTE/TOE. Only in a minority of cases was CTA used for procedural purposes. In any case, CTA might represent a valid tool to locate, size, and define the optimal working projection for PVL closure.

Despite all the technical difficulties mentioned, we observed a high success rate (94%) in our cohort, higher than reported in previously published studies1013. There are some plausible explanations for such a high procedural success rate. First, this is a more contemporary series, demonstrating the increasing experience of operators with complex structural procedures. Second, the use of mother-and-child techniques in one-quarter of patients and arterio-arterial loops in 25% of cases20 were paramount in this setting as delivery catheters are generally difficult to advance. Third, in the presence of small leaks, lower profile AVP-III and AVP-4 devices were delivered via 5 Fr, 6 Fr, or even 4 Fr diagnostic catheters, reducing the need for larger catheters and sheaths and subsequently avoiding excessive manipulation8. Fourth, in this systematic review of 14 studies, the definition of successful PVL closure following TAVI varied widely, ranging from mild or trivial AR to a significant reduction of AR post-procedure10. However, the largest series included in this systematic review, conducted by Saia et al12, utilised a definition of procedural success with a final grade AR ≤2, which corresponds to mild-to-moderate PVL severity and is consistent with the definition used in our study.

The use of devices designed for other settings such as ventricular septal defects, atrial septal defects, or patent ductus arteriosus closure devices (i.e., Amplatzer Septal Occluder device, Amplatzer Duct Occluder, Amplatzer Vascular Plug II or the Amplatzer Muscular VSD Occluder; all Abbott) has been extrapolated to the percutaneous PVL closure scenario. These devices present several potential limitations in this context, mainly derived from the shape and the need for large delivery catheters, resulting in a lower success rate8. The Occlutech Paravalvular Leak Device (PLD) and the AVP-III obtained the CE mark (European conformity) in 2014 and 2020, respectively, for percutaneous PVL closure. However, neither have yet obtained U.S. Food and Drug Administration approval821.

Saia et al12 reported a high rate of periprocedural complications (29.7%) in 27 patients as compared to the 12.5% observed in our cohort. Again, the increasing experience of operators, the use of vascular closure devices, and/or the minimalistic approach using radial access resulted in a lower rate of general anaesthesia use and major bleedings compared to this previous series12 (48% vs 40% and 3.7% vs 0%, respectively). The advantages of radial over femoral access have been shown in other clinical scenarios, such as PCI or conventional post-surgical PVL closure2223.

The potential clinical benefit from aortic PVL closure corresponds to the amount of PVL reduction achieved8151921. A percutaneous leak reduction to ≤mild has been associated with a significant mortality reduction during long-term follow-up in patients with surgically implanted prostheses1519. However, in previous studies focusing on the percutaneous post-TAVI PVL closure population, the prognosis remained relatively poor despite a high success rate1012. In the ReDo-TAVI registry13, the largest series that describes the efficacy of different transcatheter treatments for PVL after TAVI, patients with residual PVL ≥moderate, despite reintervention, had higher mortality at 1 year compared with patients in whom AR was reduced to ≤mild (21% vs 8%; respectively). A sustained reduction in AR post-TAVI PVL closure, resulting in a sustained improvement in NYHA Functional Class and a high survival rate (85%) during long-term follow-up, was observed in our study. The positive impact in survival benefits related to percutaneous post-TAVI PVL closure reported in our cohort could be related to the actual trend in the TAVI population: a stable proportion of elderly patients at intermediate surgical risk24, contrary to previous studies, which included inoperable patients with a high burden of comorbidities10.

Limitations

The present report has several limitations that should be acknowledged. First, the main limitation of this study is its observational design, which implies an inherent bias for several of the analysed variables. No comparison between the successful PVL closure and the failed group was possible as the subgroup sample sizes were too small. Therefore, our results should be considered hypothesis-generating. Second, the clinical and imaging results were self reported, and there was no independent adjudication. Third, there is no standard definition of procedure success for PVL closure. However, the definition used in the present study is derived from prior large retrospective observational registry studies1516. Fourth, the times between index TAVI and PVL intervention and maximum follow-up after PVL closure were unequal.

Conclusions

Percutaneous PVL closure is a feasible and safe option for treating post-TAVI leaks. Successful PVL reduction to mild or less than mild could be associated with acute and long-lasting improvements in clinical outcomes. Adequate patient selection, knowledge of equipment, techniques, and comprehensive cardiac imaging intraprocedural guidance during the procedure are imperative for achieving good results and limiting periprocedural complications.

Impact on daily practice

Despite current TAVI developments, relevant post-TAVI PVLs may still occur, potentially requiring corrective measures. Percutaneous post-TAVI PVL closure with vascular plugs might represent a valid therapeutic option. Data regarding the safety and long-term effectiveness of percutaneous post-TAVI PVL closure are scarce. Percutaneous post-TAVI PVL closure is a feasible and safe option for treating post-TAVI leaks. A high successful procedural rate was observed, which resulted in acute and long-lasting improvements in clinical outcomes.

Acknowledgements

We are grateful to Mathieu Albertini for his support in this study.

Conflict of interest statement

I.Cruz-González is aproctor for Abbott. The other authors have no conflicts of interest to declare relevant to the content of this manuscript.

Supplementary data

To read the full content of this article, please download the PDF.


References

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