Clinical research

DOI: 10.4244/EIJ-D-22-01110

Percutaneous paravalvular leak closure after transcatheter aortic valve implantation: the international PLUGinTAVI Registry

Eduardo Flores-Umanzor1, MD; Jason Nogic2, MD; Pedro Cepas-Guillén3, MD; Sebastien Hascoet4, MD; Piotr Pysz5, MD; Jose Antonio Baz6, MD; Ignacio Cruz-González7, MD; Ignacio J. Amat-Santos8,9, MD; Pablo Antúnez-Muiños7, MD; Jose Carlos González8, MD; Valeriano Ruíz-Quevedo10, MD; Rodrigo Estevez-Loureiro6, MD; Benoit Gerardin4, MD; Xavier Millan11, MD; Marcel Santaló-Corcoy12, MD; Ander Regueiro3, MD; Réda Ibrahim12, MD; Dabit Arzamendi8, MD; Eustaquio Maria Onorato13, MD; Josep Rodés-Cabau14, MD; Eric Horlick1, MD; Patrick A. Calvert2, MD; Xavier Freixa3, MD

Abstract

Background: Data regarding the safety and long-term effectiveness of percutaneous closure of paravalvular leak (PVL) after transcatheter aortic valve implantation (TAVI) are scarce.

Aims: This study aims to present a large multicentre international experience of percutaneous post-TAVI PVL closure.

Methods: All patients who underwent percutaneous post-TAVI PVL closure in 14 hospitals across Europe and North America between January 2018 and October 2022 were included.

Results: Overall, 45 patients (64% male) were enrolled. The median age was 80 years (75-84). Among them, 67% and 33% had self-expanding and balloon-expandable valve implantations, respectively. Baseline post-TAVI PVL was severe in 67% of cases and moderate in the rest. The time from index TAVI to PVL closure procedure was 16.1 (8.7-34.8) months. Most patients were in NYHA Class III and IV (73%) before the procedure, and 40% had referred hospitalisations for heart failure between TAVI and the PVL closure procedure. Successful PVL closure was achieved in 94%, reducing regurgitation to ≤mild in 91% and moderate in the rest. The Amplatzer Valvular Plug III was the most frequently used device (27 cases), followed by...

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Volume 19 Number 5
Aug 7, 2023
Volume 19 Number 5
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