The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)


Leaflet thrombosis and clinical events after TAVR: are paravalvular leaks a crucial trigger?

EuroIntervention 2018;14:716-717. DOI: 10.4244/EIJ-D-00348L

1. Department of Cardiovascular Surgery, German Heart Center Munich, Technische Universität München, Munich, Germany; 2. Insure (Institute for Translational Cardiac Surgery, Department of Cardiovascular Surgery, German Heart Center Munich at the Technical

With great interest, we read the recent paper by Rashid et al1. Their meta-analysis of six observational studies revealed that leaflet thrombosis is associated with a significantly increased risk of adverse cerebrovascular events. With this important study, evidence is accumulating that (subclinical) valve thrombosis has important clinical consequences. Subclinical leaflet immobility and valve thrombosis have been reported with both transcatheter and surgical aortic valve bioprostheses, but more commonly in transcatheter than in surgical valves2,3. While leaflet thrombosis causing early valve failure occurs in just 1% of TAVR valves, subclinical valve thrombosis has been observed in 7%-10% of implanted TAVR valves4.##...

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