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In vivo assessment of the three-dimensional haemodynamic micro-environment following drug-eluting bioresorbable vascular scaffold implantation in a human coronary artery: fusion of frequency domain optical coherence tomography and angiography

EuroIntervention 2013;9:890 published online ahead of print July 2013. DOI: 10.4244/EIJV9I7A147

1. Cardiovascular Division, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, USA; 2. Thoraxcenter, Erasmus University Medical Centre, Rotterdam, The Netherlands; 3. Department of Materials Science and Engineering, Unive
The biplane angiographic data, acquired after implantation of an everolimus-eluting bioresorbable vascular scaffold (Absorb™ BVS; Abbott Vascular, Santa Clara, CA, USA) in the right coronary artery of a 46-year-old patient, were separately fused with frequency domain optical coherence tomography (FD-OCT) and intravascular ultrasound (IVUS) data to reconstruct the three-dimensional (3-D) anatomy. The local shear stress (SS) distribution in the FD-OCT- and IVUS-based models was assessed using computational fluid dynamics. The FD-OCT-based reconstruction (Figure 1A) allowed imaging of the lumen irregularities in the scaffolded segment due to strut protrusion (Figure 1B), which caused recirculation zones around the struts (Figure 1C). In ...

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