Original Research

DOI: 10.4244/EIJ-D-23-00713

Impact of hyperaemic stenosis resistance on long-term outcomes of stable angina in the ILIAS Registry

Coen K.M. Boerhout1, MD; Mauro Echavarría-Pinto2, MD, PhD; Guus A. de Waard3, MD, PhD; Joo Myung Lee4, MD, PhD; Hernán Mejía-Rentería5, MD, PhD; Seung Hun Lee6, MD, PhD; Ji-Hyun Jung7, MD; Masahiro Hoshino8, MD; Hitoshi Matsuo8, MD, PhD; Maribel Madera-Cambero9, MD; Ashkan Eftekhari10, MD, PhD; Mohamed A. Effat11, MD; Tadashi Murai12, MD; Koen Marques1, MD, PhD; Joon-Hyung Doh13, MD, PhD; Evald H. Christiansen14, MD, PhD; Rupak Banerjee15, PhD; Chang-Wook Nam16, MD, PhD; Giampaolo Niccoli17, MD, PhD; Masafumi Nakayama18,19, MD, PhD; Nobuhiro Tanaka20, MD, PhD; Eun-Seok Shin21, MD, PhD; Marcel A.M. Beijk1, MD, PhD; Niels van Royen3, MD, PhD; Paul Knaapen1, MD, PhD; Javier Escaned5, MD, PhD; Tsunekzu Kakuta12, MD, PhD; Bon-Kwon Koo22, MD, PhD; Jan J. Piek1, MD, PhD; Tim P. van de Hoef1,23, MD, PhD; Martijn Meuwissen24, MD, PhD

Abstract

BACKGROUND: The hyperaemic stenosis resistance (HSR) index was introduced to provide a more comprehensive indicator of the haemodynamic severity of a coronary lesion. HSR combines both the pressure drop across a lesion and the flow through it. As such, HSR overcomes the limitations of the more traditional fractional flow reserve (FFR) or coronary flow reserve (CFR) indices.

AIMS: We aimed to identify the diagnostic and prognostic value of HSR and evaluate the clinical implications.

METHODS: Patients with chronic coronary syndromes (CCS) and obstructive coronary artery disease were selected from the multicentre ILIAS Registry. For this study, only patients with combined Doppler flow and pressure measurements were included.

RESULTS: A total of 853 patients with 1,107 vessels were included. HSR more accurately identified the presence of inducible ischaemia compared to FFR and CFR (area under the curve 0.71 vs 0.66 and 0.62, respectively; p<0.005 for both). An abnormal HSR measurement was an independent and important predictor of target vessel failure at 5-year follow-up (hazard ratio 3.80, 95% confidence interval: 2.12-6.73; p<0.005). In vessels deferred from revascularisation, HSR seems to identify more accurately those vessels that may benefit from revascularisation rather than FFR and/or CFR.

CONCLUSIONS: The present study affirms the theoretical advantages of the HSR index for the detection of ischaemia-Âinducing coronary lesions in a large CCS population. (Inclusive Invasive Physiological Assessment in Angina Syndromes Registry [ILIAS Registry], ClinicalTrials.gov: NCT04485234)

Sign in to read
the full article

Forgot your password?
No account yet?
Sign up for free!

Create my pcr account

Join us for free and access thousands of articles from EuroIntervention, as well as presentations, videos, cases from PCRonline.com

Volume 20 Number 11
Jun 3, 2024
Volume 20 Number 11
View full issue


Key metrics

Suggested by Cory

CLINICAL RESEARCH

10.4244/EIJV12I2A33 Jun 10, 2016
Basal stenosis resistance index derived from simultaneous pressure and flow velocity measurements
van de Hoef TP et al
free

10.4244/EIJV13I2A20 Jun 2, 2017
Coronary physiological parameters at a crossroads
Davies J et al
free

10.4244/EIJV16I14A204 Feb 19, 2021
Ischaemic risk stratification after deferral of revascularisation on the basis of fractional flow reserve
Echavarria-Pinto M and van de Hoef TP
free
Trending articles
152.9

Clinical research

10.4244/EIJ-D-20-01125 Oct 20, 2021
An upfront combined strategy for endovascular haemostasis in transfemoral transcatheter aortic valve implantation
Costa G et al
free
47.8

NEW INNOVATION

10.4244/EIJ-D-15-00467 Feb 20, 2018
Design and principle of operation of the HeartMate PHP (percutaneous heart pump)
Van Mieghem NM et al
free
39.1

Clinical research

10.4244/EIJ-D-22-00558 Feb 6, 2023
Permanent pacemaker implantation and left bundle branch block with self-expanding valves – a SCOPE 2 subanalysis
Pellegrini C et al
free
38.95

State-of-the-Art

10.4244/EIJ-D-23-00912 Oct 7, 2024
Optical coherence tomography to guide percutaneous coronary intervention
Almajid F et al
free
X

The Official Journal of EuroPCR and the European Association of Percutaneous Cardiovascular Interventions (EAPCI)

EuroPCR EAPCI
PCR ESC
Impact factor: 7.6
2023 Journal Citation Reports®
Science Edition (Clarivate Analytics, 2024)
Online ISSN 1969-6213 - Print ISSN 1774-024X
© 2005-2024 Europa Group - All rights reserved