In this issue of EuroIntervention, we share an Expert Review on endomyocardial biopsy; a Viewpoint on high-risk plaque interventions; original research on the clinical impact of non-culprit plaque rupture; IMRCT for non-invasive CMD assessment; the reproducibility of QFR in FAVOR III Europe; a Research Correspondence on STEMI in large coronary arteries; and more...