The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)

Coronary sinus narrowing for the treatment of refractory angina A multi-center prospective open-label clinical study (The REDUCER-I study)

DOI: 10.4244/EIJ-D-20-00873

1. Cardiovascular Center, ZNA Middelheim Hospital, Lindendreef Antwerp Belgium, Belgium
2. GVM Care & Research Maria Cecilia Hospital Cotignola, Italy, Italy
3. King’s College Hospital, Denmark Hill, UK, United Kingdom
4. Elisabeth Hospital Essen, Germany, Germany
5. Bradford Teaching Hospitals NHS Foundation Trust, UK, United Kingdom
6. UMC Utrecht, Netherlands 
7. St Thomas’ Hospital Cardiothoracic Centre, London, UK, United Kingdom
8. Tel Aviv Medical Center and Sackler School of Medicine, Tel Aviv University, Israel, Israel
Disclaimer:

As a public service to our readership, this article - peer reviewed by the Editors of EuroIntervention and external reviewers - has been published immediately upon acceptance as it was received in the last round of revision. The content of this article is the responsibility of the authors.

Please note that supplementary movies are not available online at this stage. Once a paper is published in its edited and formatted form, it will be accompanied online by any supplementary movies.

To read the full content of this article, please log in to download the PDF.

Aim: To examine the safety and efficacy of the coronary sinus (CS) Reducer in improving angina severity and quality of life in patients suffering from angina pectoris, refractory to medical and interventional therapies.

Methods and Results: Patients with refractory angina pectoris (n=228; 81% male, 68.3±9.6 years) were enrolled to this multi-center, non-randomized observational study , with up to 2 year follow-up. Patients with Canadian Cardiovascular Society (CCS) class 2-4 were treated with Reducer implantation in the CS. Procedural success rate was 99%, with only one adjudicated possible procedural or device-related MACE. Mean CCS class decreased from 2.8±0.6 at baseline, to 1.8±0.7 at 2 years. Improvement in ≥1 CCS class was observed in 82%, and in ≥2 CCS classes in 31% of patients at 2 years. At baseline 70% of the cohort reported CCS class III-IV, this portion was reduced to 15% at follow up. Additional measured parameters of functional class and quality of life were also improved.

Conclusions: Interim results from the ongoing REDUCER-I study confirm the high safety profile of this therapy in patients suffering from refractory angina. The results also demonstrate sustained improvement in angina severity and in quality of life out to 2 years.

Sign in to read and download the full article

Forgot your password?
No account yet? Sign up for free!
Create my pcr account

Join us for free and access thousands of articles from EuroIntervention, as well as presentations, videos, cases from PCRonline.com

Read next article
Near-infrared spectroscopy carotid plaque characteristics and cerebral embolism in carotid artery stenting using first-generation stent