Coronary interventions

Effects of coronary sinus Reducer implantation on oxygen kinetics in patients with refractory angina

EuroIntervention 2021;16:e1511-e1517. DOI: 10.4244/EIJ-D-19-00766

Carlo Zivelonghi
Carlo Zivelonghi1, MD; Maayan Konigstein2, MD; Alessia Azzano1, MD; Pierfrancesco Agostoni1, MD, PhD; Yan Topilski2, MD; Shmuel Banai2, MD; Stefan Verheye1, MD, PhD
1. Antwerp Cardiovascular Center, Ziekenhuis Netwerk Antwerpen Middelheim, Antwerp, Belgium; 2. Tel Aviv Medical Center, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel

Aims: Refractory angina is still a major public health problem. The coronary sinus Reducer (CSR) has recently been introduced as an alternative treatment to reduce symptoms in these patients. The aim of this study was to investigate objective improvements in effort tolerance and oxygen kinetics as assessed by cardiopulmonary exercise testing (CPET) in patients suffering from refractory angina undergoing CSR implantation.

Methods and results: In this multicentre prospective study, patients with chronic refractory angina undergoing CSR implantation were scheduled for CPET before the index procedure and at six-month follow-up. The main endpoints of this analysis were improvements in VO2 max and in VO2 at the anaerobic threshold (AT). Clinical events and improvements in symptoms were also recorded. A total of 37 patients formed the study population. The CSR implantation procedure was successful and without complications in all. At follow-up CPET, significant improvement in VO2 max (+0.97 ml/kg/min [+11.3%]; 12.2±3.6 ml/kg/min at baseline vs 13.2±3.7 ml/kg/min, p=0.026), and workload (+12.9 [+34%]; 68±28 W vs 81±49 W, p=0.05) were observed, with non-significant differences in VO2 at the AT (9.84±3.4 ml/kg/min vs 10.74±3.05 ml/kg/min, p=0.06). Canadian Cardiovascular Society (CCS) grade improved from a mean of 3.2±0.5 to 1.6±0.8 (p<0.01), and significant benefits in all Seattle Angina Questionnaire variables were shown.

Conclusions: In patients with obstructive coronary artery disease suffering from refractory angina, the implantation of a CSR was associated with objective improvement in exercise capacity and oxygen kinetics at CPET, suggesting a possible reduction of myocardial ischaemia.

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Coronary interventionsStable CADOther coronary interventions
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