The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)

Coronary sinus Reducer implantation results in improved oxygen kinetics at cardiopulmonary exercise test in patients with refractory angina

DOI: 10.4244/EIJ-D-19-00766

1. Antwerp Cardiovascular Center, Ziekenhuis Network Antwerpen Middelheim, Antwerp, Belgium, Belgium
2. Tel Aviv Medical Center, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel
3. Antwerp Cardiovascular Center, Ziekenhuis Netwerk Antwerpen Middelheim, Antwerp, Belgium
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Aims. Refractory angina is still a major public health problem. The Coronary Sinus Reducer (CSR) has recently been introduced as an alternative treatment to reduce symptoms in these patients. Aim of this study is to investigate objective improvements in effort tolerance and oxygen kinetics as assessed by cardiopulmonary exercise testing (CPET) in patients suffering from refractory angina undergoing CSR implantation.

Methods and Results. In this multicentre prospective study, patients with chronic refractory angina undergoing CSR implantation were scheduled for CPET before the index procedure and at 6-month follow-up. Main endpoints of this analysis were improvements in VO2 max and in VO2 at anaerobic threshold (AT). Clinical events and improvements in symptoms were also recorded. A total of 37 patients formed the study population. CSR implantation procedure was successful and without complications in all. At follow-up CPET significant improvement in VO2 max (+0.97 ml/kg/min [+11.3%], 12.2±3.6 ml/kg/min at baseline vs 13.2±3.7 ml/kg/min, p=0.026), and workload (+12.9[+34%]; 68±28 W vs 81±49W, p=0.05) were observed, with non-significant differences in VO2 at AT (9.84±3.4 ml/kg/min vs 10.74±3.05 ml/kg/min, p=0.06). Canadian Cardiovascular Society (CCS) grade improved from a mean of 3.2±0.5 to 1.6±0.8 (p<0.01), and significant benefits in all Seattle Angina Questionnaire variables were shown.

Conclusions. In patients with obstructive coronary artery disease suffering from refractory angina, the implantation of CSR was associated with objective improvement in exercise capacity and oxygen kinetics at CPET, suggesting a possible reduction of myocardial ischemia.

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