The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)
Clinical Outcomes of Proximal Optimization Technique (POT) in Bifurcation Stenting
Bernard Chevalier1.; Mamas Mamas2; Thomas Hovasse3; Muhammad Rashid2; Joan Antoni Gomez4; Manuel Pan5; Adam Witkowski6; James Crowley7; Adel Aminian8; John McDonald9; Farzin Beygui10; Javier Fernandez Portales11; Ariel Roguin12; Goran Stankovic13;
1. Ramsay Generale de Sante, ICPS, Hopital Jaques Cartier, Massi, France, France 2. Department of Cardiology, University Hospital of North Midlands, Stoke on Trent, UK; Keele Cardiovascular Research group, centre of prognosis research, Institute of primary care sciences, Keele University, Stoke on Trent, UK 3. Ramsay Générale de Santé, ICPS, Hôpital Jacques Cartier, Massy, France 4. Heart Disease Institute, Bellvitge University Hospital (IDIBELL), University of Barcelona, Barcelona, Spain 5. Reina Sofia Hospital, Department of Cardiology. University of Córdoba (IMIBIC). Cordoba, Spain 6. Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland 7. Department of Cardiology, University Hospital Galway, Ireland 8. Centre Hospitalier Universitaire de Charleroi, Department of Cardiology, Charleroi, Belgium 9. Department of Cardiology, Royal Blackburn Hospital, United Kingdom 10. Department of Interventional Cardiology and Cardiology Research Units, CHU Caen, France 11. Department of Cardiology, Complejo Universitario Hospital de Caceres, Spain 12. Department of Cardiology, Hillel Yafe Medical Center, Hadera, Israel 13. Department of Cardiology, Clinical Center of Serbia, University of Belgrade, Belgrade, Serbia
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Background: Optimal deployment of coronary stents in a bifurcation lesion remains a matter of debate.
Aims: We sought to capture the daily practice of bifurcation stenting by means of a worldwide registry and to investigate how the post-implantation deployment techniques influence the clinical outcomes.
Methods: Data from the e-ULTIMASTER registry were used to perform an analysis of 4395 patients undergoing percutaneous coronary intervention for bifurcation lesions. Inverse probability of treatment weights (IPTW) propensity score methodology was used to adjust for any baseline differences. The primary outcome of interest was target lesion failure (TLF) at 1-year (follow-up rate 96.2%).
Results: Global one-year TLF rate was low: 5.1%. Proximal optimization technique was used in 33.9 % of cases and was associated with a reduction in adjusted TLF rate [4.0 (95% confidence interval:3.0-5.1)% versus 6.0(5.1-6.9)%, p<0.01] due to a reduction of all components of this composite endpoint, except for cardiac death. Stent thrombosis was also positively impacted [0.4(0.04-0.7)% versus 1.3(0.8-1.7)%, p<0.01]. POT benefit was uniform across subgroups.
Conversely, the use of kissing balloon technique (36.5%) did not influence the adjusted TLF rate.
Conclusions: Despite a low one-year failure rate in this large bifurcation stenting cohort, proximal optimization technique was associated with a further reduction in the event rate and a uniform benefit across subgroups suggesting systematic use of this deployment technique regardless of the bifurcation anatomy and stenting technique.