The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)

Characterization of a novel percutaneous closed chest swine model of ischemic mitral regurgitation guided by contrast echocardiography

DOI: 10.4244/EIJ-D-19-00095

1. Ludwig Boltzmann Cluster for Cardiovascular Research at the Center for Biomedical Research, Medical University of Vienna, Vienna, Austria, AUSTRIA
2. Ludwig Boltzmann Cluster for Cardiovascular Research at the Centre for Biomedical Research, Medical University of Vienna, Vienna, Austria
3. Ludwig Boltzmann Cluster for Cardiovascular Research at the Centre for Biomedical Research, Medical University of Vienna, Vienna, Austria
4. Ludwig Boltzmann Cluster for Cardiovascular Research at the Centre for Biomedical Research, Medical University of Vienna, Vienna, Austria
5. Ludwig Boltzmann Cluster for Cardiovascular Research at the Centre for Biomedical Research, Medical University of Vienna, Vienna, Austria
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Introduction: Alternative approaches for mitral valve repair are being constantly developed. Even though the safety of these devices has been extensively assessed in healthy animals before approval for first-in-man studies, often the efficacy of these new devices has been hardly challenged in vivoin the setting of MR. Therefore, reliable and reproducible preclinical animal models of MR are crucial to allow not only the safety assessment but also the efficacy evaluation of these novel approaches.

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