Trial Design
DOI: 10.4244/EIJ-D-24-00203
Cangrelor versus crushed ticagrelor in patients with acute myocardial infarction and cardiogenic shock: rationale and design of the randomised, double-blind DAPT-SHOCK-AMI trial
Zuzana Motovska1, MD, PhD; Ota Hlinomaz2,3, MD, CSc; Jan Mrozek4, MD, PhD; Petr Kala5, MD, PhD; Tobias Geisler6, MD, MHBA; Milan Hromadka7, MD, PhD; Ibrahim Akin8, MD, PhD; Jan Precek9, MD, PhD; Jiri Kettner10, MD, CSc; Pavel Cervinka11,12, MD, PhD; Gilles Montalescot13, MD, PhD; Jiri Jarkovsky14, MSc, PhD; Jan Belohlavek15, MD, PhD; Josef Bis12, MD, PhD; Jan Matejka16, MD, PhD; Alexandra Vodzinska17, MD; Tamilla Muzafarova1, MD; Pavol Tomasov18, MD, PhD; Alexander Schee19, MD, MBA; Stanislav Bartus20, MD; Andrea Andrasova21, MD; Christoph B. Olivier22, MD; Ales Kovarik23, MD; Petr Ostadal24,25, MD, PhD; Regina Demlova26, MD, PhD; Lenka Souckova26, PharmD, PhD; Ivan Vulev3, MD, PhD, MPH; Zdeněk Coufal27, MD; Janusz Kochman28, MD, PhD; Iuri Marinov29, MD, CSc; Jacek Kubica30, MD, PhD; Gregory Ducrocq31, MD, PhD; Michal Karpisek32, MEng; Zdenek Klimsa33, MD; Martin Hudec34, MD; Petr Widimsky1, MD, DrSc; Deepak L. Bhatt35, MD, MPH, MBA; DAPT-SHOCKAMI study group
1. Cardiocentre, Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Prague, Czech Republic; 2. First Department of Internal Medicine – Cardioangiology, ICRC, Faculty of Medicine, Masaryk University and St. Anne’s University Hospital, Brno, Czech Republic; 3. CINRE, Bratislava, Slovak Republic; 4. Cardiovascular Department, University Hospital Ostrava and Faculty of Medicine, University Ostrava, Ostrava, Czech Republic; 5. Department of Internal Medicine and Cardiology, Faculty of Medicine of Masaryk University and University Hospital Brno, Brno, Czech Republic; 6. Department of Cardiology and Angiology, University Hospital/Eberhard Karls University, Tübingen, Germany; 7. Department of Cardiology, University Hospital and Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic; 8. First Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany; 9. Department of Internal Medicine I – Cardiology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, Olomouc, Olomouc, Czech Republic; 10. Cardiology Department, Institute of Clinical and Experimental Cardiology, Prague, Czech Republic; 11. Department of Cardiology, Krajska zdravotni a.s., Masaryk Hospital and Jan Evangelista Purkyně University, Ústí nad Labem, Czech Republic; 12. 1st. Department of Medicine – Cardioangiology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic; 13. Sorbonne Université, ACTION Study Group, INSERM UMRS 1166, Institut de Cardiologie, Pitié-Salpêtrière Hospital (Assistance Publique-Hôpitaux de Paris), Paris, France; 14. Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic; 15. Second Department of Internal Medicine, Cardiovascular Medicine, General Teaching Hospital, First Faculty of Medicine, Charles University, Prague, Czech Republic; 16. Department of Cardiology, Pardubice Hospital, Pardubice, Czech Republic; 17. Department of Cardiology, Hospital Agel Trinec-Podlesi, Trinec, Czech Republic; 18. Cardiology Department, Hospital Liberec, Liberec, Czech Republic; 19. Cardiocenter, Regional Hospital Karlovy Vary, Karlovy Vary, Czech Republic; 20. Institute of Cardiology, Jagiellonian University Medical College, Kraków, Poland and Department of Cardiology, University Hospital, Kraków, Poland; 21. Cardiocenter Nitra, Nitra, Slovak Republic; 22. Cardiovascular Clinical Research Center (CCRC), Department of Cardiology and Angiology, University Heart Center Freiburg – Bad Krozingen, Faculty of Medicine, University of Freiburg, Freiburg, Germany; 23. Cardiocenter, Regional Hospital Ceske Budejovice, Ceske Budejovice, Czech Republic; 24. Department of Cardiology, Na Homolce Hospital, Prague, Czech Republic; 25. Department of Cardiology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic; 26. CZECRIN, Faculty of Medicine, Masaryk University and St. Anne’s University Hospital, Brno, Czech Republic; 27. T. Bata Regional Hospital Zlin, Zlin, Czech Republic; 28. Department of Cardiology, Medical University of Warsaw, Warsaw, Polan; 29. Institute of Hematology and Blood Transfusion, Prague, Czech Republic; 30. Department of Cardiology and Internal Medicine, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland; 31. Department of Cardiology, FACT (French Alliance for Cardiovascular Trials), DHU-FIRE, Bichat-Claude Bernard University Hospital, Paris, France; 32. BioVendor R&D, BioVendor-Laboratory Medicine, Brno, Czech Republic; 33. Department of Cardiology, Jihlava Hospital, Jihlava, Czech Republic; 34. Department of Acute Cardiology, SUSCCH, Banska Bystrica, Slovak Republic; 35. Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, USA
