Immediate and follow-up outcomes of drug-coated balloon angioplasty in de novo long lesions on large coronary arteries

DOI: 10.4244/EIJ-D-23-00502

Pier Pasquale Leone
Pier Pasquale Leone1,2, MD, MSc; Angelo Oliva1,2, MD; Damiano Regazzoli2, MD; Mauro Gitto1,2, MD; Laura Novelli1,2, MD; Ottavia Cozzi2, MD; Giulio Giuseppe Stefanini1,2, MD, MSc, PhD; Marco Luciano Rossi3, MD; Alessandro Sticchi1,2, MD; Francesco Tartaglia1,2, MD; Antonio Mangieri2, MD; Bernhard Reimers2, MD; Antonio Colombo1,2,3, MD
1. Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy; 2. Cardio Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy; 3. EMO-GVM Centro Cuore Columbus, Milan, Italy
Drug-coated balloon (DCB) angioplasty offers a novel strategy for the treatment of coronary artery disease. It yields non-inferior clinical outcomes compared with drug-eluting stent (DES) implantation in patients with in-stent restenosis and de novo small vessel disease1. When an acceptable angiographic result is achieved after lesion preparation in de novo lesions, DCB angioplasty allows delivery of the antiproliferative drug to the vessel wall while avoiding implantation of permanent metallic struts and their long-term consequences2. Evidence regarding DCB angioplasty in de novo lesions of large coronary vessels is scant.

The observational, retrospective DCB 3.0 cohort study included a total ...

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