Device-related thrombus following left atrial appendage occlusion

EuroIntervention 2022;18:. DOI: 10.4244/EIJ-D-21-01010

Trevor Simard
Trevor J. Simard1, MD; Benjamin Hibbert2, MD, PhD; Mohamad A. Alkhouli1, MD; Neena S. Abraham3, MD; David R. Holmes Jr1, MD
1. Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA; 2. Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; 3. Department of Gastroenterology and Hepatology, Mayo Clinic, Scottsdale, AZ, USA

Thrombus formation on intracardiac devices remains a subject of importance, with rates in the 2-5% range. Device-related thrombus (DRT) following left atrial appendage occlusion is an area of particular concern considering its association with embolic events. DRT continues to present numerous questions, including the optimal definition, incidence, risk factors, monitoring, therapy, and clinical outcomes – all subjects of ongoing assessment. Herein, we discuss these considerations, building upon the relevant historical context and pathophysiologic insights while discussing the future considerations in this rapidly evolving field.

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