2. Medizinische Klinik und Poliklinik für Kardiologie, Angiologie und innere Intensivmedizin, Mainz, Germany.
3. Cardiocenter, Third Faculty of Medicine, Charles University in Prague, University Hospital Kralovske Vinohrady, Prague, Czech Republic.
4. Institute of Cardiology, Hospital of Bellvitge, Barcelona, Spain
5. Cardiology Department, Interventional Cardiology Unit, Virgen de la Arrixaca Hospital, Murcia, Spain.
6. Cardiovascular Institute, Hospital Clinic. University of Barcelona, IDIBAPS. Spain.
7. Institute of Cardiology, Hospital of Bellvitge, Barcelona, Spain.
8. Imperial College, London, UK
As a public service to our readership, this article - peer reviewed by the Editors of EuroIntervention - has been published immediately upon acceptance as it was received. The content of this article is the sole responsibility of the authors, and not that of the journal or its publishers.
Please note that supplementary movies are not available online at this stage. Once a paper is published in its edited and formatted form, it will be accompanied online by any supplementary movies.
To read the full content of this article, please download the PDF. Download full article (PDF)
Methods and results: This observational and retrospective study included 235 consecutive STEMI patients treated by BRS, compared with 235 STEMI patients treated with EES from the EXAMINATION trial, by applying propensity score matching. Primary endpoint was a device-oriented endpoint (DOCE), including cardiac death, target vessel myocardial infarction and target lesion revascularization at 5-year follow-up.Device thrombosis, according to the ARC criteria, was also evaluated.Optical coherence tomography (OCT) analysis was also performed at 5-year in event-free BRS patients. The cumulative incidence of 5-year DOCE was higher in BRS as compared to EES group (13.2% vs. 7.6%, HR [95%CI] 1.87 [0.94 – 3.44], p=0.071), mainly driven by higher rate of TLR (7.6% vs. 1.7%, HR [95%CI] 1.15 [0.44 – 2.30], p=0.004). Five-year definite BRS thrombosis rate was also higher as compared to EES (4.2% vs. 1.2%, HR [95%CI] 3.49 [0.95 – 12.82], p=0.054. Optical coherence tomography analysis showed high incidence of neo-atherosclerosis in BRS group.
Conclusions: Five-year event risk was higher with BRS vs EES in STEMI. This suggests that the probability of obtaining favorable results at very long-term follow-up is low. Whether better results will be obtained with new generation BVS remains to be determined.
Sign in to read and download the full articleForgot your password?
Join us for free and access thousands of articles from EuroIntervention, as well as presentations, videos, cases from PCRonline.com