Volume 21 Number 21

This issue of EuroIntervention opens with the rationale and design of the PROTECT IV trial before moving to original research on routine prasugrel or ticagrelor use in myocardial infarction; an acute coronary syndrome substudy of the OCCUPI Trial and blood pressure changes following renal denervation. This issue also includes a research correspondence on renal denervation and kidney disease and a flashlight that recounts a concertina effect mimicking plaque rupture on OCT; and more...

Snapshot

The PROTECT IV trial; Denmark’s shift in routine prasugrel or ticagrelor use; OCT vs angiography in ACS patients; blood pressure changes after renal denervation; renal denervation and kidney disease; a concertina effect mimicking plaque rupture on OCT; and more

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Trial Design

Mechanical circulatory support in high-risk elective PCI: rationale and design of the PROTECT IV trial

Mangner N, Sharma S, O’Connor C, Kaki A, Dangas G, Moses J, Mahmud E, Tarantini G, Achenbach S, Pocock S, O’Neill W, Grines C, Lansky A, Wollmuth J, Narula J, Karmpaliotis D, Faraz H, Basir M, Bharadwaj A, Ali Z, Simonton C, Bilazarian S, Kapur N, Chapman R, Bentley D, Popma J, Maehara A, Windecker S, Stone G

10.4244/EIJ-D-25-00486

Original Research

Impact of shifting from routine use of ticagrelor to prasugrel in myocardial infarction patients after PCI: a nationwide cohort study

Jacobsen M, Graversen P, Jabbari R, Grove E, Glinge C, Holmvang L, Geisler T, Køber L, Torp-Pedersen C, Engstrøm T, Sorensen R

10.4244/EIJ-D-25-00132

Editorial comment

Closing the loop: from evidence to everyday care

Kastrati A, Simonetti F

10.4244/EIJ-E-25-00047

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Optical coherence tomography-guided percutaneous coronary intervention in acute coronary syndrome patients with complex lesions: a subgroup analysis of the randomised OCCUPI Trial

Lee Y, Kim Y, Lee O, Cho D-K, Lee S, Lee S, Lee J, Kim J, Kim S, Hur S-H, Heo J, Jang J, Koh J, Won H, Lee J, Hong S, Kim D-K, Choe J, Lee J, Yang T-H, Lee J, Hong Y, Ahn J, Hong S, Ahn C, Kim J, Ko Y, Choi D, Hong M, Jang Y, Kim B, obotOi

10.4244/EIJ-D-25-00478

Editorial comment

A clear-sighted view is what is needed in a rough sea

Adriaenssens T, Frederiks P

10.4244/EIJ-E-25-00048

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Impact of baseline systolic blood pressure on blood pressure changes following renal denervation

Schmieder R, Mahfoud F, Mancia G, Townsend R, Kandzari D, Kario K, Bhatt D, Whitbourn R, Liu M, Böhm M

10.4244/EIJ-D-24-01131

Research Correspondence

Long-term effects of radiofrequency-based renal denervation on blood pressure and renal function by degree of renal dysfunction

Galli V, Galuppi E, Tavella D, Gangemi C, Gambaro A, Casal M, Trevisanello A, Fezzi S, Scarsini R, Ferrero V, Pesarini G, Gambaro G, Ferraro P, Ribichini F

10.4244/EIJ-D-25-00217

Flashlight

Concertina effect mimicking plaque rupture in a patient presenting with acute coronary syndrome

Chandra Mohan N, Johnson T

10.4244/EIJ-D-25-00333