The business of risk

EuroIntervention 2018;13:1503-1505. DOI: 10.4244/EIJV13I13A241

Ryan Lennon
Ryan J. Lennon, MS; David R. Holmes Jr*, MD
Mayo Clinic, Rochester, MN, USA

Predictions about the future feature prominently in all aspects of human endeavour from weather to economics to politics and, increasingly, to medicine. In cardiovascular disease where scientists often deal with strategies of care, the design of clinical trials is greatly influenced by consideration of risk in the patients to be treated; in this case, issues of patient population, baseline demographics and predicted event rates are used to design sample size and power calculations. For patients, risk prediction is less ethereal, instead being very concrete and of the utmost importance because the potential endpoints to be predicted are often ...

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