Clinical research

DOI: 10.4244/EIJ-D-22-01037

Clinical outcomes of transcatheter mitral valve replacement: two-year results of the CHOICE-MI Registry

Sebastian Ludwig1,2,3, MD; Nils Perrin4, MD; Augustin Coisne3,5, MD, PhD; Walid Ben Ali4, MD, PhD; Jessica Weimann1, MSc; Alison Duncan6, MD; Mariama Akodad7, MD; Andrea Scotti3,8, MD;Daniel Kalbacher1,2, MD; Sabine Bleiziffer9, MD; Georg Nickenig10, MD; Jörg Hausleiter11, MD; Hendrik Ruge12,13, MD; Matti Adam14, MD; Anna S. Petronio15, MD; Nicolas Dumonteil16, MD; Lars Sondergaard17, MD; Marianna Adamo18, MD; Damiano Regazzoli19, MD; Andrea Garatti20, MD; Tobias Schmidt21, MD; Gry Dahle22, MD, PhD; Maurizio Taramasso23, MD; Thomas Walther24, MD; Joerg Kempfert25, MD; Jean-François Obadia26, MD; Omar Chehab27, MD; Gilbert H.L. Tang28, MD, MSc, MBA; Azeem Latib8, MD; Sachin Goel29, MD; Neil Fam30, MD; Martin Andreas31, MD, PhD; David W. Muller32, MD; Paolo Denti33, MD; Fabien Praz34, MD; Ralph Stephan von Bardeleben35, MD; Juan F. Granada3, MD; Thomas Modine36, MD, PhD; Lenard Conradi37*, MD; CHOICE-MI Investigators (collaborators)


Background: Transcatheter mitral valve replacement (TMVR) using dedicated devices is an alternative therapy for high-risk patients with symptomatic mitral regurgitation (MR).

Aims: This study aimed to assess the 2-year outcomes and predictors of mortality in patients undergoing TMVR from the multicentre CHOICE-MI Registry.

Methods: The CHOICE-MI Registry included consecutive patients with symptomatic MR treated with 11 different dedicated TMVR devices at 31 international centres. The investigated endpoints included mortality and heart failure hospitalisation rates, procedural complications, residual MR, and functional status. Multivariable Cox regression analysis was applied to identify independent predictors of 2-year mortality.

Results: A total of 400 patients, median age 76 years (interquartile range [IQR] 71, 81), 59.5% male, EuroSCORE II 6.2% (IQR 3.8, 12.0), underwent TMVR. Technical success was achieved in 95.2% of patients. MR reduction to ≤1+ was observed in 95.2% at discharge with durable results at 1 and 2 years. New York Heart Association Functional Class had improved significantly at 1 and 2 years. All-cause mortality was 9.2% at 30 days, 27.9% at 1 year and 38.1% at 2 years after TMVR. Chronic obstructive pulmonary disease, reduced glomerular filtration rate, and...

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Volume 19 Number 6
Aug 21, 2023
Volume 19 Number 6
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