The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)

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The influence of shear stress on in-stent restenosis and thrombosis

EuroIntervention Supplement (2008) Vol. 4 (Supplement C) C27-C32.

Thoraxcenter, Cardiology Department, Erasmus MC, Rotterdam, The Netherlands
Introduction

Stent implantation during coronary intervention has been shown to be very beneficial to maintain blood flow through the arteries after treating coronary stenosis. In bare metal stents, after a period of six months neointimal hyperplasia growth compromises the lumen in 26% of the cases, requiring repeated catheterisation1. With the advent of drug eluting stents, restenosis rates are decreased tremendously on the account of a very small percentage late thrombosis risk (2.6%)1. Rheologic factors has been shown to be involved in numerous processes, including neointimal growth and thrombus formation. The formation of neointimal hyperplasia in stented arteries has been linked to ...

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