Trial Design

DOI: 10.4244/EIJ-D-24-00437

Temporal modulation (early escalation and late de-escalation) of antiplatelet therapy in patients undergoing complex high-risk PCI: rationale and design of the TAILORED-CHIP trial

Hanbit Park1, MD; Do-Yoon Kang2, MD; Jung-Min Ahn2, MD; Sung-Cheol Yun3, PhD; Kyoung-Ha Park4, MD; Se-Hun Kang5, MD; Jon Suh6, MD; Jang-Whan Bae7, MD; Sangwoo Park8, MD; Jang Hyun Cho9, MD; Jung-Won Suh10, MD; Bong-Ki Lee11, MD; Seung-Woon Rha12, MD; Hoyoun Won13, MD; Jae-Sik Jang14, MD; Moo Hyun Kim15, MD; Cheol Hyun Lee16, MD; Young Keun Ahn17, MD; Jun-Hyok Oh18, MD; Jae-Seok Bae19, MD; Chul Soo Park20, MD; Jaewoong Choi21, MD; Jin-Bae Lee22, MD; Se-Whan Lee23, MD; Sung-Ho Hur24, MD; Osung Kwon25, MD; Seung-Jung Park2, MD; Duk-Woo Park2, MD; on behalf of the TAILORED-CHIP trial investigators

Abstract

Despite the use of conventional dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI), the risk of adverse events remains high among patients with increased thrombotic risk. Until recently, the optimal antiplatelet strategy to balance the ischaemic and bleeding risks in patients who are undergoing complex high-risk PCI has been unclear. The TAILored Versus COnventional AntithRombotic StratEgy IntenDed for Complex HIgh-Risk PCI (TAILORED-CHIP) trial is an investigator-initiated, multicentre, prospective randomised trial to evaluate the efficacy and safety of a time-dependent tailored antiplatelet therapy with an early (<6 months post-PCI) escalation (low-dose ticagrelor at 60 mg twice daily plus aspirin) and a late (>6 months post-PCI) de-escalation (clopidogrel monotherapy) in patients undergoing complex high-risk PCI as compared with standard DAPT (clopidogrel plus aspirin for 12 months). Eligible patients had to have at least one high-risk anatomical or procedural feature or clinical characteristic associated with an increased risk of ischaemic or thrombotic events. The primary endpoint was the net clinical outcome, a composite of death from any cause, myocardial infarction, stroke, stent thrombosis, urgent revascularisation, or clinically relevant bleeding (Bleeding Academic Research Consortium type 2, 3, or 5) at 12 months after randomisation. (ClinicalTrials.gov: NCT03465644)

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Volume 20 Number 21
Nov 4, 2024
Volume 20 Number 21
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