The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)
Expert review
Impact of single or multicentre study design on the results of trials examining the efficacy of adjunctive devices to prevent distal embolisation during acute myocardial infarction
Yoichi Inaba1*, MD; Jennifer A. Chen2, MD; Nisha Mehta2, MD; Steven R. Bergmann3, MD, PhD
1. Division of Cardiovascular Medicine, Oregon Health and Science University, Portland, OR, USA; 2. Division of Medicine, Beth Israel Medical Center, New York, NY, USA; 3. Division of Cardiology, Beth Israel Medical Center, New York, NY, USA
Aims: We investigated using meta-analytic techniques, whether, and to what degree, single or multicentre study design affects clinical outcomes in randomised controlled trials examining the