The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)


Drug-eluting stent implantation in acute myocardial infarction. Do we need another randomised trial? (TYPHOON, PASSION and HORIZONS trials)


Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
The goal of treatment of patients with acute myocardial infarction (AMI) is to achieve optimal and rapid restoration of coronary blood flow in the infarct-related vessel and to maintain the initial result at follow-up. There are two main treatment methods of re-opening an occluded artery: administrating a thrombolytic agent and primary percutaneous coronary intervention (PCI) with or without stenting. In the 1990s and the beginning of the 2000s, many randomized studies comparing these two reperfusion procedures have shown that primary PCI with routine stent implantation for AMI has a better outcome than thrombolytic therapy1,2 or balloon angioplasty3-5. A recent ...

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