This issue of EuroIntervention opens with an Expert Review on the ELASTA-T technique for transcatheter tricuspid valve replacement; we then offer a Viewpoint on transcatheter therapies for aortic regurgitation; followed by Original Research on renal function and antithrombotic therapies; Original Research on device depth and flow dynamics in left atrial appendage closure; the Trial Design of the NAPT-LAAC trial; and more...