In this issue of EuroIntervention, we offer you an expert review on non-invasive diagnosis of coronary dysfunction; a viewpoint reconsidering the “5S s” of excimer laser coronary atherectomy PCI; original research on the outcomes of intravascular imaging-guided PCI in ACS patients; absolute coronary flow after PCI; chronic limb-threatening ischaemia outcomes with drug-coated devices; and a flashlight on percutaneous closure for transcarotid TAVI; and more...