The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)

Experimental research

Shear stress is associated with markers of plaque vulnerability and MMP-9 activity

EuroIntervention 2006;2:250-256 - DOI10.4244/EIJV2I2A42.

1. Thorax center, Erasmus MC, Rotterdam, The Netherlands; 2. Middelheim, Antwerp, Belgium; 3. Department Experimental Cardiology Utrecht The Netherlands; 4. Department of Vascular Surgery, Erasmus MC, Rotterdam, The Netherlands

Background: Vulnerable plaque has been associated with local macrophage accumulation and local high matrix metalloproteinase-2 (MMP-2) and MMP-9 activity. Since shear stress is a known local modulator of plaque l

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