Objective
to perform a head-to-head comparison of FFR- and IVUS-guided PCI with regard to clinical and patient-reported outcomes in those with intermediate coronary stenosis.
Study
investigator-initiated, multicentre, prospective, randomised, openlabel trial.
Population
adult patients with de novo stenosis of 40-70% in a vessel of at least 2.5 mm by visual estimation on coronary angiography (excluding LM disease).
Endpoints
the primary outcome was a composite of all cause death, MI, or any revascularisation at 24 months
Conclusion
for patients with intermediate coronary stenosis who were being evaluated for PCI, FFR guidance was noninferior to IVUS guidance with respect to the composite primary outcome of death, myocardial infarction or revascularisation at 24 months.
Koo et al. NEJM. 2022; 387:779-89
