10. Lesion haemodynamic assessment and PCI

FFR vs CAG-guided strategy in acute MI

FRAME-AMI
Objective
to compare the clinical adverse outcomes of FFR-guided PCI with angiographyguided PCI for non-infarct related lesion in patients with multi-vessel disease and acute MI
Study
investigator-initiated, open-label, multicentre randomised trial
Population
patients with STEMI or NSTEMI undergoing successful PCI and having 1 or more non-infarct related lesion
Endpoints
composite of time to death, MI or repeat revascularisation at a median follow-up of 3.5 years
Conclusion
selective PCI using FFR-guided decision-making was superior to angiography-guided decision-making in patients with acute MI and multi-vessel disease
Lee et al. European Heart Journal 2023; 44: 473-84
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