11. Antithrombotic therapies

COBRA PzF stenting to reduce duration of triple therapy

COBRA-REDUCE
Objective
to demonstrate that the COBRA PzF stent with 14 days of DAPT post-stenting was superior in terms of bleeding and noninferior in terms of thromboembolic events when compared to new-generation DES and 3 to 6 months of DAPT post-stenting
Study
prospective, multicentre, open-label, parallel group-randomised trial(noninferiority margin 5%)
Population
patients with stable or unstable angina or acute coronary syndrome and oral anticoagulation
Endpoints
bleeding: BARC Class 2 (occurring beyond 14 days and 6 months), thromboembolic within 14 days
Conclusion
Byrne et al. Circulation Cardiovasc Interv. 2024 Oct;17:e013735
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