Objective
to compare the adverse clinical events of 1 month dual antiplatelet (DAPT-1) therapy followed by clopidogrel with 12-month dual antiplatelet therapy (DAPT-12)
Study
open-label multicentre randomised inferiority trial (margin 2.3%)
Population
patients with successful PCI with CoCR-EES stent without in-hospital MACE (except periprocedural MI)
Endpoints
composite of cardiovascular and bleeding events: cardiovascular death, MI, definite stent thrombosis, stroke or TIMI major or minor bleeding
Conclusion
1 month DAPT followed by clopidogrel (monotherapy) compared to 12 month DAPT (aspirin and clopidogrel) was associated with lower cardiovascular MACE and bleeding
Watanabe et al. JAMA. 2019;321:2414-27
