Detection of Cholesterol Crystals by Optical Coherence Tomography
Hiroyuki Jinnouchi1; Yu Sato1; Sho Torii1; Atsushi Sakamoto1; Anne Cornelissen1; Rahul R. Bhoite1; Salome Kuntz1; Liang Guo1; Ka Hyun Paek1; Raquel Fernandez1; Frank D. Kolodgie1; Renu Virmani1; Aloke V. Finn2, ;
1. CVPath Institute, Gaithersburg, MD 2. CVPath Institute, Gaithersburg, MD, United States, United States
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The accuracy of OFDI/OCT for detecting cholesterol crystals (CCRs) and its pathophysiological significance are uncertain. This study sought to determine ability of OFDI/OCT to visualize CCR. A total of 559 cross-sectional OFDI/OCT images from autopsy cases were co-registered with histology. The sensitivity of OFDI/OCT for detection of CCRs was low but their detection correlates with the presence of stacked cholesterol clefts (CC) (defined as CC arranged one on top of another in greater than 3 layers). CCR by OFDI/OCT indicates presence of late stage plaque.